Two individual have been rushed to hospital while nine others demand been hurt after the double-decker bus and 4×4 vehicle collided on the A78, looming the Rowan Tree restaurant in Ardrossan, North Ayrshire just after 2pm.
The Scottish Ambulance Usage has declared the scene a major incident.
Two air ambulances are currently at the scene, along with adept trauma teams.
A Police Scotland spokesman said: “We responded to sundry reports of a serious road traffic collision at 14.10 on the A78 at Rowan Tree in Ardrossan.
“It complex two vehicles, a double decker bus and a truck. Emergency services are in attendance and amusements are in place.
“One person has been pronounced dead at the scene and two people bring into the world been taken to the Queen Elizabeth University Hospital by air and by road ambulance.
“Nine others from been treated at the scene or transferred to Crosshouse Hospital for observations.”
Policewomen said that local diversions were in place via West Kilbride and Dalry as the highway had been closed in both directions.
The bus involved was operated by by the Stagecoach bring.
A spokeswoman for the bus’s operator added: “The service involved was the Service 585 from Greenock to Ayr.
“Our to begin thoughts are with those affected by this incident. The safety of our voyagers and staff is our highest priority and we are assisting the police fully with their analysis into the circumstances.”
A spokesman for the Scottish Fire and Rescue Service judged: “Our crews are at the scene of a serious road collision on the A78.
“We received a cry from the ambulance service at 2.15pm today and firefighters reached the happening three minutes later.
“There were six appliances at the scene and firefighters plied alongside police and ramedics to assist those involved.”
A spokesman for the ambulance armed forces said: “There are 11 casualties, several of whom are in a uncertain condition.”
The identities and ages of the victims are unknown at this time.