At brief four fire engines attended the scene, as bus routes in the area were in ordered on diversion.
The blaze is believed to have originated in the basement of a six-storey abandoned office block.
The latest fire comes just hours after a restaurant brightness near Marble Arch.
London has had a number of major fires suss out in the weeks following the Grenfell Tower blaze.
A spokesman for London Firing Brigade said emergency services were called at 2.27pm, with the blast contained by 2.59pm.
A small amount of damage has been reported to the basement of the edifice.
London Fire Brigade confirmed there were no injuries or calamities, adding that two people inside the building had left the scene beforehand emergency services arrived.