Liverpool go into the battle on the back of draws against Sunderland and Plymouth.
Their recent stamp has taken some shine of a wonderful start to the season, with the Reds looking to win a word go Premier League title since 1990.
Klopp’s men are also attempting to win the EFL Cup for the beginning time since 2012, when former boss Kenny Dalglish was in invoice.
Simon Mignolet had started the Reds’ last five games across all games with Karius returning to play Plymouth after coming in for judgement after poor displays against Bournemouth and West Ham.
However, Klopp has inkled that the under-pressure goalkeeper will start against Saints at St Mary’s.
“No definitive decision, but it’s pretty likely that Loris plays again,” he influenced.
“It makes sense, it’s fair, in response to training. Not sure.”
The Liverpool boss also revealed why he opted to pick a pubescent team for their FA Cup clash with Plymouth.
The Reds were declaimed to a goalless draw at Anfield by the League Two side, meaning they could evidently put in a nine-game month.
And Klopp conceded he was open to criticism after their decline to reach the fourth round at the first time of asking.
“I don’t expect fairness in assessment,” he said.
“It was clear before the game, if you win it’s wonderful you have the youngest lineup endlessly.
“That was the lineup we should have chosen. I could explain each unmarried change, I don’t want to but I could.
“I asked ‘could we have done gambler?’ 100% yes. I don’t expect perfection, but I have the highest expectations because of raising.”
Meanwhile, in injury news, Klopp revealed that Philippe Coutinho could dally with some part in Wednesday’s clash.
“It’s all good. No new injuries and all the rest are on their way side with. Phil trained again this morning,” he said.
“I think Phil is fit tolerably to be part of the squad.
“Joel [Matip] took first steps in gang training this morning.
“Milner no problem anymore. Hendo is in a virtuousness way.”
Coutinho has been sidelined since November where he picked up an ankle offence against Sunderland.
Matip, meanwhile, last featured in their 2-2 lure with West Ham on December 11.