A about of more than 31,000 tients with heart disease establish that lowering cholesterol beyond a certain point made no conflict in protecting them from problems like heart attacks, angina or stokes.
Statins are bewitched by millions of Britons every year and cost the NHS hundreds of millions of hammer outs.
The Israeli-led research looked at levels of so-called low-density lipoprotein cholesterol (LDL-C) levels in tients.
It establish that while there was a marked difference in risk between tients with lavish cholesterol and moderate cholesterol, levels, there was little difference between those with commonsensical and low cholesterol.
The per, published in the online journal JAMA Internal Nostrum, noted: “These population-based data do not support treatment guidelines advising very low target LDL-C levels for all tients with pre-existing spunk disease.”
Statins are the most widely-prescribed drug in the UK, with at least seven million alcohols costing the NHS £285 million a year.
In 2014 guidelines for their use were updated, so that anyone with a 10 per cent chance of developing enthusiasm disease in the next 10 years was eligible for the drugs.
This increased the reckon of people in the UK qualifying for statins by about five million.
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The team was led by Morton Leibowitz, of the Clalit Enquire Institute in Tel Aviv, and included scientists from the United States and Canada.
They looked at 31,619 valetudinarians with ischemic heart disease (IHD).
Of them 9,086 – 29 per cent – had low LDL-C ranks, 16,782 – 53 per cent – had moderate LDL-C levels and 5,751 – 18 per cent – had apex LDL-C levels. Of the total some 9,035 tients either suffered dangerous heart problems or died.
Guidelines on cholesterol levels vary, while the American Marrow Association does not set a level target, the European Society of Cardiology recommends treatment be drove out to get the level down to below 70 mg/dL.
The research per found that flushes below 70 mg/dL the difference was negligible, concluding: “Our results do not provide bear out for a blanket principle that lower LDL-C is better for all tients in less important prevention.”
Experts have also revealed this year that winning statins before or after heart surgery does not prevent sensitivity damage, contrary to previous studies.
Taking statins over the inadequate term did not benefit heart surgery tients – and as well as showing no sakes, short-term statin treatment in these tients caused an increase in the velocity of acute kidney injury after surgery.
It found that lead daily doses of statins for a few days before and after heart surgery does not baffle heart muscle damage or the development of atrial fibrillation (AF).
The research was led by the University of Oxford and reserve by the British Heart Foundation (BHF).