The new delve into suggests that vitamin E and selenium supplements, taken alone or in syndication, did not prevent or delay dementia in older men who are not showing any symptoms.
Antioxidants as budding treatment for cognitive impairment or dementia have been of interest for years because oxidative significance has been implicated as a dementia pathway.
The Prevention of Alzheimer’s Disease by Vitamin E and Selenium clinical pain in the arse initially enrolled 7,540 older men who used the supplements for an average of on touching five years and a subset of 3,800 men who agreed to be observed longer.
The men endured either vitamin E, selenium, both or a placebo, but the study did not look at balls.
The incidence of dementia was not different among the study groups, according to Dr Richard Kryscio, of the University of Kentucky, Lexington, who led the on.
The authors pointed out that there were limitations to the study as they misspent about half of the participants to long-term follow-up.
This was because of a transmutation from a randomised clinical trial to a cohort study, but it appears the capsules did not work.
Publicity about the negative effect of supplements also may procure played a role, according to the authors.
Dr Kryscio added: «The supplemental use of vitamin E and selenium did not delay dementia and are not recommended as preventive agents.
«This conclusion is tempered by the underpowered haunt, inclusion of only men, a short supplement exposure time, dosage considerations and methodologic limitations in relying on real-world disclosing of incident cases.»
The data was published online today by JAMA Neurology.