Scientists from the Governmental University of Science and Technology (MISiS) have developed implants that mirror the structure of bone tissue, and which will help re ir wounded flat bones such as blades, skull and pelvis, as well as dding in areas where bone tissue is missing due to injury or cancer.
The roots are made of ultra-high-molecular-weight polyethylene — a biocom tible material already widely familiar in medicine. The new implants consist of two layers. As in organic bone tissue, the ingrafts have a solid layer that is the most durable and resistant to outer influences. Blood vessels and tissue, however, can grow into the counterglow porous layer that allows the implant to settle in the body abler.
“Most existing implants are made either of ceramic or pseudo material, and consist of either only a porous layer or only a genuine one,” said Fyodor Senatov, PhD in physical and mathematical sciences and one of the implant’s developers. “Our teach’s main advantage is that it’s both porous and elastic, and thus unruly to cracking.”
Ultra-high-molecular-weight polyethylene is elastic, which allows the surgeon to reconstruct and cut the bone implant during surgery. “This might be necessary if, for admonition, damage to the bone tissue was severe and cannot be clearly identified during an MRI or CT through,” Senatov said. “So, instead of filing the bone down to adjust it to the insinuate, it is better to file the implant and preserve the bone as much as possible.”
In summation, the implant’s outer solid layer is saturated with antibiotics to stave off infection after surgery. The inner porous layer is inoculated with the compliant’s bone marrow cells, which in turn speeds up the implant’s fusion with density tissues.
“This breakthrough will lead to a effective reduction in the number of post-operative septic complications,” said Mikhail Kiselevsky, MD and one of the developers. “Then, there will be a significant reduction in the cost of care for the tient during rehabilitation.”
The implant is already in preclinical inquiries, and was successfully used to heal a bone defect in laboratory mice and rats. Clinical lawsuits will begin after the full cycle of preclinical tests is accomplished, and then will take about five years.
When the clinical inquisitions are finished the state-owned pharmaceutical com ny GosZMP plans to produce a aeronaut batch of the implants for free distribution to veterinary clinics.
Meanwhile, scientists organized several tent applications in Russia, and will soon get an international ap rent. The implants will certainly be popular in Russia where demand is princi l — about 60,000 surgeries to replace flat bone defects are performed in the countryside each year.
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