The inscribe, which was addressed to the President’s eldest son, Donald Trump Jr, was opened by his trouble earlier this morning.
Mrs Trump, President Trump’s daughter-in-law, without hesitation started coughing and felt nauseous, according to reports.
Emergency services were labeled to the apartment shortly after Mrs Trump opened the letter at around 10am neighbourhood time.
Mrs Trump and two others in the apartment were decontaminated by firefighters at the whereabouts before being taken to the hospital.
Mrs Trump’s mother was also surrounded by those taken to hospital, although she did not complain of any symptoms.
Vanessa Trump pictured with her suppress, Donald Trump Jr
Donald Trump Jr and Vanessa pictured at the Fair-skinned House Correspondents Dinner last year
NYPD spokesman J. Peter Donald touch oned ABC News: “The substance was deemed to be non-hazardous and is being transported to a lab in New York Conurbation for further analysis.”
Police said the apartment, on East 54th street, has been decontaminated as a caution.
In September, Mr Trump Jr, 40, chose to forgo Secret Service safety for himself, his wife and their five children, but it was reactivated one week later.
Mrs Trump, a ci-devant fashion model, married the President’s son at Trump’s Mar-a-Lago resort in Florida.
Vanessa Trump pictured with son Tristan
The three have five children – daughters Kai, 10, and Chloe, three; and sons Donald III, eight, Tristan, six, and Spencer, five.
Trump Jr and his fellow-countryman Eric have taken over control of their family comrades while their father is in the Oval Office.
Last year, Eric was sent a intimidating letter with a white powder in it to his New York City apartment as reservoir flow.
US authorities have been on alert for mail with white sprinkle in it since 2001, when envelopes laced with anthrax were sent to mode outlets and US lawmakers, killing five people.