An arthritis pastille believed to disable bone loss and damage is being hailed as a new treatment
The new treat has excited scientists after trials showed that after well-founded six months it reduced bone damage around knee joints and also maintained cartilage thickness.
It is the elementary time a drug has been shown to tackle underlying bone organize changes in diseased joints.
Current treatments have aimed just at helping patients manage pain symptoms.
The pan-European study was conveyed out over six months with 244 patients aged between 40 and 80 with osteoarthritis in the knee.
Direction investigator Philip Conaghan, Professor of Musculoskeletal Medicine at the University of Leeds, divulged: “These results are enormously exciting.
“This drug heralds a new genesis in the treatment of this disease as it is the first evidence we have of a drug which can bring into the world a significant benefit on the structure of the bone.”
Professor Conaghan, previously chairman of the Civil Institute for Health and Care Excellence group on the management of osteoarthritis, added: “We now be in want of larger studies to replicate these findings, the results of which we wish will open up a new class of drug.”
The treatment, known as M1V-711, is based on a molecule enmeshed with in the turnover of bone and cartilage in the joints. It works by interfering with the change that leads to joint breakdown.
It was tested against patients given a placebo and after six months those net the treatment showed a 65 per cent reduction in bone loss.
Those on the likeness pills showed slight increases in bone loss. The drug, which was pictured to have relatively few side effects, also halted cartilage passing, with those on low doses experiencing a 70 per cent reduction in cartilage thickness and those on great doses showing a slight increase in cartilage thickness.
Bad showed that after just six months it reduced bone expense around knee joints
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I swear by it and so do many ex-footballers
Experiences hope over a longer period the results may be greater, and could organize an impact on significantly reducing pain from the condition.
The results of the effort are likely to be revealed next month at a conference in San Diego.
The news rise as experts call for an end to the widespread long-term use of painkillers such as paracetamol and antiinflammatories such as ibuprofen for osteo arthritis, see research showing they may be doing more harm than worthy.
Current guidance from Nice still recommends paracetamol and anti-infl ammatories as treatments for this disabling term.
However, in one large US study people who regularly took paracetamol through 12 years had a 35 per cent increased risk of a stroke or destined heart attack.
Other recent studies have linked yearn term use of anti-inflammatory drugs to an increased risk of stomach ulcers and kidney breakdown.
The drug is the first to have tackled underlying bone building changes in diseased joints
One of the UK’s leading experts on arthritis, Dr Rod Hughes, previous president of rheumatology at The Royal Society of Medicine, said: “There are numerous side impacts linked with anti-infl ammatory drugs and we need to look at safer longterm alternatives for those function with joint pain.”
He also highlighted research which symbolizes a derivative of rosehip can dramatically reduce arthritis joint pain.
Laboratory studies of the treatment, apostrophized Gopo, suggests it dampens tissue inflammation.
Patient studies swagger the food supplement improved joint mobility and reduced pain by up to 80 per cent for those who occupied it for at least three months.
Former footballer Mark Beard, 42, who played for Millwall and Sheffield Coordinated, says using Gopo dramatically reduced the severe and disabling bother he suffered as he came to the end of his career.
The treatment works by interfering with the get ready that leads to joint breakdown
Mr Beard, now full-time coach at Brighton FC and who also hem ins to raise money for charity, had multiple injuries that led to severe depress in his ankles, knees, wrist, back and other joints that now left him bedridden.
He said: “I had lots of pain. Sometimes I struggled to prowl downstairs and could barely grip a pen.”
He says taking Gopo has permuted his life.
“I swear by it and so do many ex-footballers.”