Alzheimer’s disease: Doctors detect ‘silent seizures’ that mark onset


Alzheimer's diseaseGETTY

Doctors have in the offing detected ‘silent seizures’ that mark the onset of Alzheimer’s sickness

The devastating illness begins with seizures deep in the main homage structure of the brain, known as the hippocampal region, the study claims.

Researchers set up dubbed the episodes “silent seizures” because they don’t cause convulsions and aren’t read by normal brain scans.

But American doctors say they were masterful to observe the dysfunctional patterns in two patients by using fine wires to correct electrodes into deep regions of their brains.


The vitriolic illness begins with seizures deep in the main memory

The breakthrough could lead to new therapies for the degenerative illness, mutual understanding to a study by the Baylor College of Medicine.

Dr Jeffrey Noebels, a professor of neurology and neuroscience at the association, said: “About 10 years ago, we were surprised to find “unuttered seizures” in mouse models of Alzheimer’s disease.

“When we measured the zooid’s brain electrical activity, we detected abnormal electrical discharges in the sense with a seizure-like pattern.

“The mice, however, did not present with convulsions.

We noted abnormal electrical discharges in the brain with a seizure-like pattern

Dr Jeffrey Noebels

“These ‘clinically unspoken seizures’ in the deep regions of the brain, we speculated, could lead to stews of memory.”

Doctors inserted electrodes into two human patients’ senses through small incisions in their skulls.

They were then expert to observe “clear silent seizures” that weren’t detected by burgee brain scans, known as electroencephalogram tests.

The none-convulsive seizures could be an premature warning sign in the majority of Alzheimer’s patients, who have a sporadic mode of the disease.

Dr Noebels added: “This work with two patients demonstrates the concept that ‘silent seizures’ can occur in patients with Alzheimer’s bug.”

His colleague, Dr Andrew Cole, said the seizures “could contribute to or accelerate the degenerative process underlying Alzheimer’s complaint”.

An electroencephalogram testGETTY

An electroencephalogram test

He added: “It is very invigorating that we were able to move from an observation in genetically wangled mouse models of Alzheimer’s to a demonstration of the same phenomenon in patients with verified Alzheimer’s sickness.

“This is a critical step toward a better understanding of network dysfunction in the disorder and opens the window to novel therapeutic approaches for this common demand.”


The none-convulsive seizures could be an early warning sign in the best part of Alzheimer’s patients

The report’s co-author Dr Alica Goldman added: “From a physician’s position, I think this work opened my eyes toward the need to look deeper into our patients’ brainwash in order to improve the quality of their lives as well as that of their caregivers.”

The Baylor College of Drug said the discovery “provides a better understanding of the condition and can potentially cue to new treatments for this devastating disease”.

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